Palladium-catalyzed carboetherification and carboamination reactions of γ-hydroxy- and γ-aminoalkenes for the synthesis of tetrahydrofurans and pyrrolidines

Abstract

Substituted tetrahydrofuran and pyrrolidine moieties are displayed in a wide range of interesting biologically active molecules. The Pd-catalyzed carboetherification or carboamination of γ-hydroxy and γ-aminoalkenes is a powerful tool for the construction of these heterocycles, as it is convergent and can allow access to a variety of analogs from a single γ-hydroxy- or γ-aminoalkene starting material. This microreview describes the current state of this field. © Wiley-VCH Verlag GmbH & Co. KGaA.