Myeloma associated glomerular disease

Abstract

Multiple myeloma is a plasma cell malignancy characterized by the presence of a monoclonal gammopathy, lytic bone lesions, hypercalcemia, anemia, and/or renal impairment. Renal impairment is common and most frequently occurs in the form of light chain cast nephropathy. However, in addition to cast nephropathy, the kidney can also sustain injury to the glomerulus, tubules, interstitium, and the vessels by other mechanisms, with glomerular lesions being most common. The focus of this chapter will be on the spectrum of glomerular lesions associated with multiple myeloma.