Pharmacological Therapy

Abstract

Osteoporosis is a bone metabolic disease, characterized by a decrease of bone mass and deterioration of the micro-architecture of the skeleton, which leads to an increased fracture risk. It is a multifactorial disease potentially caused by genetic mutations, endocrine disorders, and lifestyle alterations. Hormones modulate bone remodeling and maintain bone homeostasis. Osteoporosis in men is a relatively common problem, although less frequent than in women, with a prevalence of 17% versus 34%, respectively, but it is underestimated, underdiagnosed, and undertreated. In the last decade, studies of male osteoporosis have increased the awareness of the problem and have improved our understanding of the pathogenesis of osteoporosis and fragility fractures in men.