Facile preparation of unstable metabolic intermediates; epoxide (s) of pyrazolo[1,5-a]Pyridine derivatives by the cytochrome p-450 chemical model

Abstract

Biomimetic oxidation of bioactive pyrazolo[1,5-a]pyridine derivatives carried out with the chemical model for cytochrome P-450, afforded 6,7-epoxides in relatively high yields, these appear to be chemically unstable precursors of the main metabolites, i.e., 6,7-dihy-dro-6,7-diols. © 1989, The Pharmaceutical Society of Japan. All rights reserved.