Cytotoxicity and anti-HIV evaluations of some new synthesized quinazoline and thioxopyrimidine derivatives using 4-(thiophen-2-yl)-3,4,5,6- tetrahydrobenzo[h]quinazoline-2(1H)-thione as synthon

Abstract

A series of dihydrobenzo[h]quinazoline derivatives 5-19 were synthesized using arylmethylene 2, thiopyrimidine 3 and 2-(4-(thiophen-2-yl)-5,6- dihydrobenzo[h]quinazolin-2-ylthio) acetic acid (4) as a starting materials. The biological screening showed that many of these compounds have good anticancer and antiviral activities. The structure assignments of the new compounds based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties are reported. © Indian Academy of Sciences.