The polycythaemia rubra vera-1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders

Abstract

Little is known about the expression of the polycythaemia rubra vera-1 (PRF-1) gene in bone marrow cells. To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. We demonstrated that PRV-1 was constitutively expressed in both myeloproliferative and reactive states. We concluded that, rather than an upregulation of the PRF-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRF-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.