No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients with and without Giant Cell Arteritis

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Abstract

Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

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Verdijk, R. M., Ouwendijk, W. J. D., Kuijpers, R. W. A. M., & Verjans, G. M. G. M. (2021). No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients with and without Giant Cell Arteritis. Journal of Infectious Diseases, 223(1), 109–112. https://doi.org/10.1093/infdis/jiaa566

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