Bence Jones cast nephropathy

Abstract

Patients with Bence Jones cast nephropathy usually present with acute renal failure (less commonly with chronic renal failure) and Bence Jones proteinuria. It has been known for many years that intravenous radiocontrast media, dehydration, infections, and the use of nonsteroidal antiin-fl ammatory drugs may induce the precipitation of renal tubular light chain casts and result in acute renal failure, which is reversible in only a small percent of affected patients. A less common manner of presentation is the acquired Fanconi syndrome. This is most often associated with intracellular crystals in plasma cells and tubular cells; the crystals represent the abnormal light chain (2,3). © 2007 Springer New York.