High-Throughput Screening Application For the Determination of Enantiomeric Excess Using ESI-MS

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Abstract

Methods for the rapid determination of the enantiomeric excess (ee%) of organic substrates, especially for HTS, are often the "bottleneck" in a process. For this purpose, a new process of entirely automated sample preparation and the determination of ee% using electrospray ionization-mass spectrometry (ESI-MS) has been developed. Various substrates and new auxiliaries were explored to enhance the methodical scope. In combination with a very versatile liquid-handling system (HTS-PAL) and a comprehensive processing equipment, a multitude of standardized reaction vessels can be managed with the presented system. As an example of use, the ee% determination of 1-phenylethanole via ESI-MS is compared to state-of-the-art GC analysis. In addition, a HTS suitable data processing network was constructed that allows postrun data manipulation and the automated data transfer to analysis and visualization templates with a maximum amount of automation. © 2006 The Association for Laboratory Automation.

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Gördes, D., & Thurow, K. (2006). High-Throughput Screening Application For the Determination of Enantiomeric Excess Using ESI-MS. JALA - Journal of the Association for Laboratory Automation, 11(3), 128–133. https://doi.org/10.1016/j.jala.2006.03.006

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