Viable count and viability of Bifidobacterium bacteria in fermented milk products on the market

  • Tayama K
  • Okamoto Y
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Abstract

Background:\rMetastatic bone disease is a common cause of pain in cancer patients. A multidisciplinary approach \rto treatment is often necessary because simplifi\r ed analgesic regimens may fail in the face of complex pain \rgenerators, especially those involved in the genesis of neuropathic pain. From the origins of formalized guidelines\rby the World Health Organization (WHO) to recent developments in implantable therapies, great strides have \rbeen made to meet the needs of these patients.\rMethods:\r The authors review the existing literature on the pathophysiology and treatment options for pain \rgenerated \rby metastatic bone disease and summarize classic and new approaches.\rResults:\r Relatively recent animal models of malignant bone disease have allowed a better understanding of \rthe intimate mechanisms involved in the genesis of pain, resulting in a mechanistic approach to its treatment. \rAnalgesic strategies can be developed with specifi\r c targets in mind to complement the classic, opioid-centered \rWHO analgesic ladder obtaining improved outcomes and quality of life. Unfortunately, high-quality evidence \ris diffi\r cult to produce in pain medicine, and these concepts are evolving slowly.\rConclusions:\r Treatment options are expanding for the challenging clinical problem of painful metastatic bone \rdisease. Efforts are concentrated on developing alternative nonopioid approaches that appear to increase the \rsuccess rate and improve patients’ quality of life.

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Tayama, K., & Okamoto, Y. (2013). Viable count and viability of Bifidobacterium bacteria in fermented milk products on the market. Journal for the Integrated Study of Dietary Habits, 24(2), 118–123. https://doi.org/10.2740/jisdh.24.118

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