Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying mechanisms and crosstalk with other oncogenic factors, we developed the NRL-PRL mouse. In this model, mammary expression of a rat PRL transgene raises local exposure to PRL without altering estrous cycling. Nulliparous females develop metastatic, histotypically diverse mammary carcinomas independent from ovarian steroids, and most are ER+. These characteristics resemble the human clinical disease, facilitating study of tumorigenesis, and identification of novel preventive and therapeutic approaches.
CITATION STYLE
O’Leary, K. A., Shea, M. P., & Schuler, L. A. (2015). Modeling Prolactin Actions in Breast Cancer In Vivo: Insights from the NRL-PRL Mouse. Advances in Experimental Medicine and Biology, 846, 201–220. https://doi.org/10.1007/978-3-319-12114-7_9
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