Gene expression profiling is a powerful tool to analyze the complexity of cancer biology. Recent methods allow the generation of gene expression profiles for all known genes in the human genome. The genome-wide analysis of the gene expression patterns of neoplastic and normal cells provides insights into: (1) the identification of previously unknown tumor subtypes; (2) the normal cellular counterparts of tumor cells; (3) the identification of cellular pathways that may be affected by malignant transformation; (4) the identification of new diagnostic markers and potential therapeutic targets. This chapter summarizes experimental approaches addressing these goals using examples from studies on B-cell malignancies.
CITATION STYLE
Basso, K., & Dalla-Favera, R. (2007). Gene expression profile analysis of tumors. Methods in Molecular Biology (Clifton, N.J.), 383, 67–79. https://doi.org/10.1007/978-1-59745-335-6_5
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