Formation of a class of enzyme inhibitors (drugs), including a chiral compound, by using imprinted polymers or biomolecules as molecular-scale reaction vessels

Abstract

Two mutually complementary, target-directed synthetic approaches have been used to generate a class of bio-effective molecules (inhibitors). In the first, condensation reactions were performed within the cavities of a molecularly imprinted polymer (MIP) prepared against a known kallikrein inhibitor. In the second approach, the enzyme itself directed the assembly of small building blocks within the biologically active site (see scheme).