Handbook of Schizophrenia Spectrum Disorders, Volume II

Abstract

Obsessive-compulsive features are common in schizophrenia. The term schizo-obsessive has been proposed to delineate this subgroup of schizophrenia patients who also present OCS/OCD. Research into clinical, neuropsychological and functional profiles of schizo-obsessive patients has been extensive during these last years altough a specific profile has yet to emerge. In addition, the neurobiological and genetic underpinnings of this association have recently begun to be investigated with preliminary but promising results. This chapter reviews the validity of schizo-obsessive disorder. The clinical and neuropsychological profile is elucidated and possible pathophysiological mechanisms and etiologic factors are discussed. Finally, a suitable therapeutic approach is also suggested.