Anaplastic, or undifferentiated, thyroid cancer is one of the most aggressive solid tumors with an extremely poor prognosis. It is believed that around 50 % of anaplastic thyroid cancers arise from a prior or coexistent differentiated thyroid carcinoma. The loss of the tumor suppressor gene p53 is an important step in this process.
CITATION STYLE
Connolly, C., & Glaholm, J. (2014). Anaplastic thyroid cancer. In Tips and Tricks in Endocrine Surgery (pp. 143–147). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2146-6_17
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