Novel targets of miR-30, a microRNA required for biliary development

9Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

MicroRNAs have been found to play a profound role in embryonic and post-natal development through their regulation of processes such as cell proliferation, differentiation, and morphogenesis. The microRNA-30 (miR-30) family is necessary for vertebrate hepatobiliary development; however, the mechanism through which miR-30 regulates these processes is not fully understood. Here, we identify genes directly regulated by miR-30 that have been characterized as key developmental factors. The targets were confirmed via a luciferase reporter assay, following exogenous over-expression of miR-30a and miR-30c2 in cultured cells. Five novel miR-30ac2 targets were identified using this approach, all of which play crucial roles in hepatobiliary development or are involved in hepatocellular carcinoma and cholangiocarcinoma.

Cite

CITATION STYLE

APA

Friedman, J. R., Le Guen, C. L., & Hand, N. J. (2013). Novel targets of miR-30, a microRNA required for biliary development. F1000Research, 2. https://doi.org/10.12688/f1000research.2-197.v1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free