Clinical validation of a radionuclide detector to measure ejection fraction in critically ill patients

Abstract

Summary: The use of a new non-imaging nuclear probe (Cardioscint) capable of continuous online monitoring of left ventricular function is described in critically ill patients undergoing mechanical ventilation. Ejection fraction, measured by the Cardioscint, was compared with that measured by echo-cardiography. The mean difference was -1.1% (95% confidence interval -2.9 to +0.6%). Mean difference±2 SD was +10.6 to -12.8% (95% confidence intervals +7.5 to + 13.6% and - 15.8 to -9.0%, respectively). Examples of fluid loading and inotropic support showed comparable changes in stroke counts measured by the Cardioscint and stroke index measured by thermodilution. The Cardioscint is a practical bedside method for continuous or repeated measurement of ejection fraction and for assessing the response to therapeutic interventions in critically ill patients. (Br. J. Anaesth. 1994; 72: 523-528). © 1994 British Journal of Anaesthesia.