Anticancer diketopiperazines from the marine fungus

Abstract

Diketopiperazines (DKPs) of marine resources, especially those isolated from marine-derived fungi, have been paid increasing attention for their diversity in chemical structure and bioactivity. In this chapter, the marine-fungi derived DKPs with cytotoxic, cell cycle progression inhibiting, or apoptosis-inducing activities, are displayed with the classification according to their functionalities into three groups including prenylated DKPs, thio-DKPs, and simple DKPs, each of which is subsequently sorted referring to their structural features or composing in amino acid residues.