Oncogene signal transduction inhibitors from Chinese medicinal plants

Abstract

Oncogene modulated signal transduction based on intracellular phosphorylation of protein tyrosine or serine/threonine has been utilized as a target or oncogene-based anti-cancer drug discovery. Inhibition of protein-tyrosine kinase and protein kinase C directed prescreen has identified numerous potential anti-tumor Chinese medicinal plants. Further bioassay-guided fractionation and separation have led to the discovery of novel protein kinase inhibitors, anthraquinones, stilbenes and polythiophenes as potential anti-tumor agents. © 1999 IUPAC.