Serological and structural comparison of immunodeficiency viruses from man, african green monkey, rhesus monkey and sooty mangabey

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Abstract

W e have studied the serological relationship among the human immunodeficiency virus type 1 (HIV-1), and three simian immunodeficiency viruses (SIV). SIVagm was isolated from African green monkeys (Cercopithecus aethiops), and compared with the previously described isolates of SIVmac from a rhesus macaque (Macaca mulatta) and SIVsm from a sooty mangabey (Cercocebus atys). With respect to the glycoproteins, the simian viruses represent a subgroup apparently different from H I V. T o classify H I V and SIV isolates further, we compared tryptic peptide maps of the core polypeptides p18 and p24 of HIV-2, three HIV-1 and five SIV isolates. Each peptide map was distinguishable, and differences are most prominent between the HIV-1 group and the SIVmac/SIVsm group. HIV-2 is very similar to SIVmac and SIVsm. The three SIVagm isolates form a more heterogeneous group. The p24s of all SIVagms are more similar to the p24s of HIV-1, but with respect to p18, one isolate is similar to HIV-1, while the two others are more related to SIVmac, SIVsm, and HIV-2. © 1988, Walter de Gruyter. All rights reserved.

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APA

Jurkiewicz, E., Hunsmann, G., Schneider, J., Hayami, M., Ohta, Y., & Schmitz, H. (1988). Serological and structural comparison of immunodeficiency viruses from man, african green monkey, rhesus monkey and sooty mangabey. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 43(5–6), 449–454. https://doi.org/10.1515/znc-1988-5-621

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