Multiscale Modeling of Diseases: Overview

Abstract

Some of the most recent advances in multiscale modeling of human diseases are briefly summarized. These progresses benefited from the rapid development of advanced multiscale modeling techniques as well as the development and availability of new mechanobiology experimental techniques and diverse imaging modalities. The close interdisciplinary collaborations between modeling scientists, experimentalists, and medical doctors enabled unprecedented quantitative understanding of human pathologies. Two specific examples are given on the recent advances in multiscale modeling of malaria – an infectious disease and sickle cell disease – a genetic disease. Future outlook is presented, followed by a brief introduction of the chapters included in this section.