Ang-(1-7) binds to the G-protein-coupled MAS receptor and exerts many beneficial actions in the context of acute inflammation. Ang-(1-7) reduces production and expression of many cytokines and adhesion molecules and decreases leukocyte movement in vitro and in vivo. In animal models of inflammation, administration of Ang-(1-7) or its analogues is, in general, associated with inhibition of leukocyte influx and inflammatory tissue damage. In addition, Ang-(1-7) reduces fibrogenesis in the context of chronic inflammation. Ang-(1-7) also induces the resolution of inflammation by inducing apoptosis of neutrophils and their clearance by macrophages. Altogether, the available literature suggests that drugs that mimic the action of Ang-(1-7) on the MAS receptor may represent a novel pharmacological strategy to control and treat inflammatory diseases.
CITATION STYLE
Galvão, I., Rago, F., Moreira, I. Z., & Teixeira, M. M. (2019). Angiotensin 1-7 and Inflammation. In Angiotensin-(1-7): A Comprehensive Review (pp. 201–218). Springer International Publishing. https://doi.org/10.1007/978-3-030-22696-1_13
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