Isolation and Characterization of Cardiac Steroids from Seeds of Elaeopendron glaucum Pers. Structures of Elaeodendrosides A, D, E, H, I, J and Elaeodendrogenin

Abstract

Six cardiac glycosides having a methylenedioxy group in the sugar moiety, elaeodendroside A, D, E, H, I and J, were isolated from seeds of Elaeodendron glaucum Pers. Their structures were elucidated on the basis of chemical correlation with elaeodendroside A, which was characterized by X-ray analysis. A new cradiac steroid named elaeodendrogenin was also isolated from the same plant materials and its structure was established by direct comparison with a synthetic sample obtained from digitoxigenin. The cardiac activities of these compounds were tested with Straub's preparation. © 1982, The Pharmaceutical Society of Japan. All rights reserved.