Hepatitis B Virus-Infected HepG2 hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8 + T Cells In Vitro

  • Hoh A
  • Heeg M
  • Ni Y
  • et al.
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Abstract

CD8 + T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8 + T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2 hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8 + T cells. This induced cytolytic and noncytolytic CD8 + T-cell effector functions and reduction of viral loads.

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Hoh, A., Heeg, M., Ni, Y., Schuch, A., Binder, B., Hennecke, N., … Thimme, R. (2015). Hepatitis B Virus-Infected HepG2 hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8 + T Cells In Vitro. Journal of Virology, 89(14), 7433–7438. https://doi.org/10.1128/jvi.00605-15

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