Functional effect of mouse embryonic stem cell implantation after spinal cord injury

Abstract

We transplanted mouse embryonic stem cells (mESCs) to improve functional loss in a rat model of clip-compression spinal cord injury (SCI). The mouse embryonic stem cells were transplanted to injured cord 7 days after injury. We include minimizing the progression of secondary injury, manipulating the neuroinhibitory environment of the spinal cord, replacing lost tissue with transplanted cells and substantial improvement of motor. A number of potential approaches optimize functional recovery after spinal cord injury. We review the application of stem cell transplantation to the spinal cord, emphasizing the use of embryonic stem cells for reconstruction of spinal cord injury. Thus, this study provides strong evidence to support that transplantation of mESC could improve functional recovery after SCI.