Platelets in Arterial Thrombosis

Abstract

The central role of the platelet in thrombus formation has been well established. Whereas thrombus formation in some situations may be protective, it can be devastating in others such as in acute coronary syndromes. An understanding of the mechanisms and the molecules involved in platelet-mediated thrombosis is essential in order to be able to devise antiplatelet regimens that may improve patient outcomes and to develop future generations of antithrombotic drugs. This chapter provides a brief summary of the molecules and mechanisms which regulate platelet adhesion and aggregation.