Internal Dosimetry: Principles and Applications to NET

Abstract

In recent years internal dosimetry added valuable information on the diagnostic and therapeutic use of radionuclide imaging and therapy of neuroendocrine tumors. This chapter provides an overview on the concepts and methods used today for obtaining dosimetry data and their linkage to biological endpoints such as DNA damage markers. Furthermore, data on absorbed doses and dose-response relationships for the kidney, bone marrow, and tumors are reported.