Injectable dermal fillers - Resorbable or permanent?

Abstract

Patients who are thinking for the first time of a wrinkle treatment should try collagen or hyaluronic acids in order to experience its effect. Restylane, Juvederm, and all other hyaluronic acids have been shown to last not longer than Zyderm or Zyplast, all about 4-6 months. If the patients are satisfied but do not want to repeat the treatment every 6 months, they should consider a long-lasting injectable like ArteFill. Arteplast's and Artecoll's side effects from the early 1990s have been abolished significantly by purification of the microspheres [35]. The effect of silicone oils and polyacrylamide gels on wrinkles has not been tested thoroughly. In larger quantities, both are followed by a high incidence of late complications. New-Fill/Sculptra and Radiesse appear to be safe and effective in larger quantities in facial defects like facial lipodystrophy or chin and malar augmentation, but do not last longer than 6-9 months beneath wrinkles. Most side effects occur after lip augmentation in the form of palpable or even visible nodules; therefore, lip augmentation should be approached very carefully by filling first the vermilion border and then adding volume to the posterior lip, preferably with the microdroplet technique. © Springer-Verlag 2007.