Factores que inciden el daño oxidativo en niños con obesidad: Estudio piloto

Abstract

Introduction: Obesity is a metabolic disorder that creates oxidizing conditions, which can generate high levels of physiological stress as well as a disturbance in the state of redox cell known as Oxidative Stress. Objective: To examine the association between the damage on chromosomal DNA and the total antioxidant capacity (TAC) in obese children with severe obesity. Methods: Participants were 11 children with a mean age and body mass index of 9.5±1.2 years and 27.7±3.3 kg/m2, respectively, from which venous blood samples were obtained to determine distinctive risk factors of metabolic syndrome, the number of DNA abasic sites (AS) and TAC levels. Biomarkers were quantified from spec-trophotometric techniques and ELISA assays. Results: Were identified 4.1±4.0x105 AS and TAC of 0.218±0.03 mmol/L, and an inverse correlation between AS and TAC (r = -0.63, p=0.038). These results suggest an imbalance in reduction-oxidation status (REDOX) wi-thin the cell. Conclusion: Increased AS and decreased TAC concentrations in the presence of severe obesity suggest that oxidative stress could be considered as an important risk factor closely linked to the early development of comor-bidities associated to obesity.