Patient-specific biomechanical model of the brain: Application to Parkinson's disease procedure

Abstract

Stereotactic neurosurgery for Parkinson's disease consists of stimulating deep nuclei of the brain. Although target coordinates are calculated with high precision on the pre-operative images, cerebrospinal fluid (CSF) leakage during the procedure can lead to a brain deformation and cause potential error with respect to the surgical planning. In this paper, we propose a patient-specific biomechanical model of the brain able to recover the global deformation of the brain during this type of neurosurgical procedure. Such a model could be used to update the pre-operative planning and balance the mechanical effects of the intra-operative brain shift. © Springer-Verlag Berlin Heidelberg 2003.