A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms.
CITATION STYLE
Kurita, M., Moriya, T., Nishino, S., Hirata, E., Hirasawa, N., Okubo, Y., & Sato, T. (2016). Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: A case report. Neuropsychiatric Disease and Treatment, 12, 3199–3203. https://doi.org/10.2147/NDT.S115648
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