A basic approach to CKD

Abstract

Metabolic acidosis often complicates chronic kidney disease (CKD) and adversely affects bone, nutrition, and metabolism. Phisitkul et al. demonstrate that sodium citrate may ameliorate kidney injury in CKD patients not on dialysis. Further, they provide evidence in humans that treatment lowers urinary endothelin levels, and hence increased endothelin may be part of the mechanism whereby acidosis hastens CKD progression. © 2010 International Society of Nephrology.