Abstract
This preclinical study was performed to evaluate the regenerative capacities of vitro-expanded amniotic fluid stem cells (AFSCs) allotransplanted within experimentally induced lesions in ovine calcaneal tendons. Explanted samples were evaluated for tendon architecture, collagen composition, AFSC retrieval, cell proliferation, blood vessel organization, and leukocyte infiltration. Tendon healing and viable AFSCs were observed within the lesion site 30 days after transplantation. AFSCs differentiated into collagen-producing cells, stimulated collagen type I deposition and fiber alignment, and exerted positive effects on angiogenesis and inflammatory reactions. Thus, as AFSCs markedly improved tendon healing, they may be used to develop innovative therapies.
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Russo, V., Marchisio, M., Pierdomenico, L., Barboni, B., Ioannoni, A., Valbonetti, L., … Berardinelli, P. (2014). Sheep calcaneal tendon repair subsequent to amniotic-derived stem cell allotransplantation. In Veterinary Science: Current Aspects in Biology, Animal Pathology, Clinic and Food Hygiene (pp. 27–32). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-23271-8_5
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