Monoaminergic Innervation of Cingulate Cortex

Abstract

discusses the morphological organization of monoaminergic projections to anterior area 24 and posterior areas 23, 30, and 29 of cingulate cortex in the rat, monkey, and human / the laminar distribution of presynaptic auto- and heteroreceptors, as well as postsynaptic somatodendritic receptors, is discussed in relation to the electrophysiological effects of monoamines on cortical neurons / by considering the pharmacological, anatomical, physiological, and biochemical interplay among 5-hydroxytryptamine (5-HT), [norepinephrine], and [dopamine] in cingulate cortex, a synthesis is pursued of their functional roles in behaviors that are regulated by cingulate cortex [motor functions, orientation and arousal, avoidance conditioning] and how dysfunction in these systems contribute to clinical manifestations of particular diseases [depression and Alzheimer's disease (AD)] (PsycINFO Database Record (c) 2000 APA, all rights reserved)