Objective: Common genetic variation spans schizophrenia, schizoaffective and bipolar disorders, but historically, these syndromes have been distinguished categorically. A symptom dimension shared across these syndromes, if such a general factor exists, might provide a clearer target for understanding and treating mental illnesses that share core biological bases. Method: We tested the hypothesis that a bifactor model of the Positive and Negative Syndrome Scale (PANSS), containing 1 general factor and 5 specific factors (positive, negative, disorganized, excited, anxiety), explains the cross-diagnostic structure of symptoms better than the traditional 5-factor model, and examined the extent to which a general factor reflects the overall severity of symptoms spanning diagnoses in 5094 total patients with a diagnosis of schizophrenia, schizoaffective, and bipolar disorder. Results: The bifactor model provided superior fit across diagnoses, and was closer to the "true" model, compared to the traditional 5-factor model (Vuong test; P
CITATION STYLE
Anderson, A. E., Marder, S., Reise, S. P., Savitz, A., Salvadore, G., Fu, D. J., … Bilder, R. M. (2018). Bifactor modeling of the positive and negative syndrome scale: Generalized psychosis spans schizoaffective, bipolar, and schizophrenia diagnoses. Schizophrenia Bulletin, 44(6), 1204–1216. https://doi.org/10.1093/schbul/sbx163
Mendeley helps you to discover research relevant for your work.