Prenatal paracetamol exposure and risk of wheeze at preschool age

33Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Aim: To analyse the association between prenatal paracetamol exposure and preschool wheeze. Methods: Data were obtained from a prospective, longitudinal study of a cohort of children born in the region of western Sweden in 2003; 8176 families were randomly selected. The parents answered questionnaires at 6 and 12 months and at 4.5 years of age. The response rate was 55%, i.e. 4496 of the 5398 questionnaires distributed at 4.5 years (83%). Inhaled corticosteroid (ICS) treated wheeze during the last year was regarded as a proxy for doctor-diagnosed asthma. Episodic viral wheeze was defined as wheezing only with viral infections and multiple-trigger wheeze as wheezing also in between infections. Results: In the multivariate analysis, the risk of ICS-treated wheeze was increased by paracetamol (OR 1.6; 95% CI 1.01-2.6). Within the ICS-treated group, the effect was significant for multiple-trigger wheeze (OR 2.4; 1.2-4.8) but not for episodic viral wheeze (OR 1.1; 0.5-2.3). Conclusion: Prenatal paracetamol exposure was an independent risk factor for ICS-treated wheeze at preschool age, especially among children with ICS-treated multiple-trigger wheeze. Although the analysis adjusted for e.g. maternal asthma and antibiotic use, the possibility of residual confounding by maternal indication (respiratory illness) should be acknowledged. © 2011 The Author(s)/Acta Pædiatrica.

References Powered by Scopus

Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach

734Citations
N/AReaders
Get full text

Clinical Pharmacokinetics of Paracetamol

452Citations
N/AReaders
Get full text

Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme

308Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Analgesic use-prevalence, biomonitoring and endocrine and reproductive effects

129Citations
N/AReaders
Get full text

Prenatal and perinatal analgesic exposure and autism: An ecological link

100Citations
N/AReaders
Get full text

Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: A systematic review and meta-analysis

90Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Goksör, E., Thengilsdottir, H., Alm, B., Norvenius, G., & Wennergren, G. (2011). Prenatal paracetamol exposure and risk of wheeze at preschool age. Acta Paediatrica, International Journal of Paediatrics, 100(12), 1567–1571. https://doi.org/10.1111/j.1651-2227.2011.02403.x

Readers over time

‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

61%

Professor / Associate Prof. 3

17%

Researcher 3

17%

Lecturer / Post doc 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 17

65%

Agricultural and Biological Sciences 5

19%

Pharmacology, Toxicology and Pharmaceut... 3

12%

Decision Sciences 1

4%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0