Esophageal motor disturbances in progressive systemic sclerosis

Abstract

Ten patients with progressive systemic sclerosis (PSS) and esophageal symptoms (group 1) and 10 control subjects were studied. Esophageal electromanometry using the intermittent pull-through technique and catheter perfusion with distilled water were performed in all patients and individuals. The variables studied were pressure amplitude in the lower esophageal sphincter (LES) (mmHg) and deglutition wave amplitude (mmHg at 5, 10 and 15 cm above LES). In PSS patients, the average LES pressure was 18.5 ± 4.6 mmHg, and in control subjects it was 27 ± 6.5 mmHg (p < 0.01). Deglutition wave amplitude at 5, 10 and 15 cm above LES was 13.2 ± 7.5 mmHg, 12 ± 3.7 mmHg and 15 ± 3.3 mmHg, respectively, in PSS patients. In control subjects, it was 67.6 ± 12.5 mmHg, 58.6 ± 20.9 mmHg and 52.4 ± 21.4 mmHg (p < 0.001). In PSS patients, the pressure amplitude in LES and in the body of the esophagus was lower than in control subjects. In PSS patients, esophageal manometry showed the absence of normal peristalsis.