Host-guest interaction driven peptide assembly into photoresponsive two-dimensional nanosheets with switchable antibacterial activity

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Abstract

Selectively controlling the bioactivity of antimicrobial peptides is not only a fascinating scientific challenge but also a necessity in localized antibacterial therapy. Here, a smart antimicrobial system has been fabricated via host-guest driven dynamic selfassembly between a branched cyclodextrin and cationic linear peptides appended with azobenzene side chains. The self-assembly structure of the host-guest system could be controlled reversibly through the photoresponsive isomerization of azobenzene moieties. Notably, trans-azobenzene side chains of the cationic peptides can interact with the branched cyclodextrin and form microscale sheet-like structures with high surface potentials. The multivalent positive charges covering the surface of the sheet-like structures enable the antibacterial features. However, the UV-triggered cis-isomerization of azobenzene residues weakens the host-guest interactions between azobenzene and the branched cyclodextrin, resulting in the formation of small and inactive nanospheres. Thus, the selective regulation of the antibacterial activity of these peptide assemblies was achieved by delivering the light with spatiotemporal precision. This kind of photoresponsive peptide self-assembly system with switchable bioactivity may provide a new insight into the development of smart supramolecular antibacterial materials.

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APA

Xie, X., Gao, B., Ma, Z., Liu, J., Zhang, J., Liang, J., … Li, W. (2021). Host-guest interaction driven peptide assembly into photoresponsive two-dimensional nanosheets with switchable antibacterial activity. CCS Chemistry, 3(7), 1949–1962. https://doi.org/10.31635/ccschem.020.202000312

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