Aluminofluoride Complexes in the Etiology of Alzheimer’s Disease

Abstract

The question of aluminum's relevance to the etiology of Alzheimer'sdisease cannot yet be adequately answered. The mechanisms of howaluminum could evoke the hallmarks of AD are not known. Reflecting manystudies, which utilize aluminofluoride complexes in laboratoryinvestigations, we suggest that these complexes may act as the initialsignal stimulating impairment of homeostasis, degeneration, and death ofthe cells. Aluminum ions in the presence of fluoride can accelerate theaging and impair the functions of the nervous system. In respect to theetiology of Alzheimer's disease, the long-term synergistic action ofaluminum ions and fluorides may represent a hidden but serious andpowerful risk factor for the development of this devastating threat tohuman civilization.