FORMULATION AND CHARACTERIZATION OF BIODEGRADABLE CHITOSAN FILMS FOR TOPICAL APPLICATION OF TERBINAFINE HCl

Abstract

Chitosan biodegradable films contg. terbinafine HCl (Tr.HCl) were evaluated for their potential drug delivery at a controlled rate. Terbinafine HCl could be loaded at 1.8% wt./wt. of polymer in films, which were translucent and flexible. The effect of drug loading and nature of plasticizers on-the-in-vitro release of Tr.HCl have been examd. Physicochem. characterization of Tr.HCl via thermal, spectroscopic, X-ray diffraction, and SEM techniques revealed information on the solid-state properties of Tr.HCl as well as chitosan in films. While chitosan was in an amorphous form, Tr.HCl seemed to be present in cryst. form in the films. It was found that the release rate of the drug was directly proportional to drug concn. Also medicated chitosan films plasticized with water-sol. plasticizers as glycerol triacetate (GTA), propylene glycol (PG), and polyethylene glycol 400 (PEG 400), produced fast release in comparison with water insol. plasticizers as glycerol tributyrate (GTB), di-Me phthalate (DMPH), and di-Et phthalate (DEPH). The characterizations of chitosan films conducted by IR, X-ray, and DSC, showed that no interaction occurred between Tr.HCl and chitosan polymer. The min. inhibitory concn. (MIC) of the drug against candida albicans was investigated. Results showed that MIC of Tr.HCl was 1.4 μg/mL. The inhibition zone diam. of Tr.HCl chitosan films was higher than that of Tr.HCl normal dressing. Also antifungal activity of Tr.HCl- was enhanced in plasticized chitosan films. The results were promising for topical formulation of Tr.HCl in biodegradable chitosan films and have the potential to be used as a novel drug delivery. [on SciFinder(R)]