Regulation of the Na+-Cl- cotransporter by dietary NaCl: A role for WNKs, SPAK, OSR1, and aldosterone

Abstract

This Commentary aims to integrate or interrelate the available data with the current study by Chiga and co-workers, which defines an important influence of aldosterone in the phosphorylation and thus activation of the Na +-Cl- cotransporter (NCC) in response to changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.