Multi-cell interaction tracking algorithm for colliding and dividing cell dynamic analysis

Abstract

Cell motion analysis contributes to research the mechanism of the inflammatory process and to the development of anti-inflammatory drugs. This paper aims to develop an accurate and robust algorithm to track multiple colliding cells and further characterize the dynamics of each cell. First, a hybrid cell detection algorithm is proposed to obtain reliable measurements in cell collision images. Second, a variant of interacting multiple models particle filter is designed for analysis of cell motion behaviors. The simulation results show that our algorithm could obtain favorable performance compared with other methods. © 2013 Springer-Verlag Berlin Heidelberg.