Natural Anti-Quorum Sensing agents against Pseudomonas aeruginosa

Abstract

Abuse of antibiotics in therapy has led to development of resistance in the target organisms. Failure of the current antibiotics to control infections makes it essential to discover alternative drugs. The pathogenicity in numerous bacteria is regulated by Quorum sensing (QS) signaling systems. The QS inhibition system may cause the reduction of virulence and defense against the bacterial infections. The QS is the main regulator of virulence and biofilm formation in Pseudomonas aeruginosa. A variety of plants showed their effects on P. aeruginosa virulence. Extract of various plants control the regulatory QS genes and factors with marginal effects on bacterial growth. The quorum-quenching (QQ) mechanisms are unrelated to static or cidal effects. In fact, anti-QS have already shown promise in the battle against P. aeruginosa infections.