Associations of serum soluble klotho and fibroblast growth factor 23 with carotid artery calcification in patients undergoing continuous ambulatory peritoneal dialysis: A retrospective study

Abstract

This study aimed to assess the associations of serum soluble klotho and fibroblast growth factor 23 (FGF-23) with the occurrence of carotid artery calcification. Peritoneal dialysis patients treated from June 2018 to June 2019 were retrospectively analyzed. They were divided into the carotid artery calcification and non-carotid artery calcification groups according to color Doppler ultrasound findings. Basic indicators in both groups were compared, and the influencing factors of carotid artery calcification were analyzed by logistic regression. Among the 73 continuous ambulatory peritoneal dialysis (CAPD) patients enrolled, 40 (54.8%) had carotid artery calcification. Significant differences were found in age (68.85±7.45 vs 46.62±5.51years), dialysis time (8.15±1.42 vs 6.02±1.14months), klotho amounts (325.56±41.15 vs 436.65±45.58pg/mL) and FGF-23 levels (114.45±15.56 vs 70.15±12.23pg/mL) between the carotid artery calcification and non-carotid artery calcification groups (all P