Immunogenicity of Bovine Serum Albumin and Its Oligopolymers in CBA Mice

Abstract

The monomer of bovine serum albumin (BSA) and its oligopolymers have been examined as immunogens in female CBA mice. When given intravenously the greatest ability not only to stimulate antibody formation but also to induce tolerance resided in the monomer. All forms were equally immunogenic if presented in complete Freund's adjuvant.These findings are discussed in relation to the elimination rate which became faster with increasing molecular size of the BSA immunogen.