Recently we developed a new water-soluble dietary fiber, an indigestible dextrin (PF-C) obtained through heat and enzyme treatment of potato starch. The physiological functions of PF-C, such as improvement of glucose tolerance and lowering of serum cholesterol level, have been confirmed. We conducted acute toxicity and mutagenicity studies, and further, we examined the effect of PF-C on bowel movement in rats as part of a safety evaluation. The results can be summarized as follows. (1) The oral LD50 value of PF-C in mice was estimated to be more than 20.0 g/kg body weight. (2) No mutagenicity was observed in Salmonella typhimunum 98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA~. (3) The excretion ratio in feces after single administration of PF-C was estimated to be 36% in rats. (4) A periodical increase of cecum weight and a decrease in pH in cecum contents were observed in rats fed a PF-C-supplemented diet. (5) Transit time of food was significantly shorter in rats fed a PF-C-supplemented diet than that in control rats. © 1992, Japanese Society for Food Hygiene and Safety. All rights reserved.
CITATION STYLE
Shigeru, W., Mitsuko, S., Yuka, U., & Kazuhiro, O. (1992). Acute Toxicity and Mutagenicity Studies of Indigestible Dextrin, and Its Effect on Bowel Movement of the Rat. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 33(6), 557. https://doi.org/10.3358/shokueishi.33.557
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