Pulse electric field effect on cancer cell properties: Reversible electroporation study

Abstract

Controlling cell function by using pulses of electrical fields have been used widely in chemotherapy application. The pulse electric field induced will create pores through the cell membrane and causes other substance around it to be absorbed into the cell. This method has led to a variety of medical applications, particularly in cell studies. In this preliminary, a range voltage of the pulse electric field used will be demonstrated. Theoretically, pulse electric field does give variety of effect on cancer cell. Which can either be a reversible electroporation or irreversible electroporation. The effect can either heal or kill the cells induced. Thus, will lead towards either cell cancer treatment factors plus the presence of electric field as the stimulator for aggressive adsorption of the anti-cancer agent into the cells or as enhancer towards wound healing applications. The outcome of this techniques will contribute towards understanding the cancer cell treatment factors which may lead towards a new method for cancer cell treatment or wound healing applications. This study will focus on applying pulse electric field on Breast cancer cell to investigate the effect of electroporation process. In addition, this study will discuss the effectiveness of low and high pulse electric field parameter, to look at anti-proliferation effect on the cancer cell towards cancer treatment applications.