Abstract
Preparation of LNA nucleosides requires a number of synthetic steps but very efficient procedures have been developed, as have protocols for synthesis of LNA oligonucleotides on automated DNA synthesizers. In all cases, LNA oligonucloetides have exhibited good aqueous solubility as would be expected from their close structural resemblance to the natural nucleic acids.
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CITATION STYLE
APA
Wengel, J., Petersen, M., Frieden, M., & Koch, T. (2007). Chemistry of Locked Nucleic Acids (LNA). In Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules (pp. 114–132). Springer US. https://doi.org/10.1007/0-387-32956-0_7
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