Free Amino Group Transfer via α-Amination of Native Carbonyls

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Abstract

We report herein a straightforward transfer of a free amino group (NH2) from a commercially available nitrogen source to unfunctionalized, native carbonyls (amides and ketones) resulting in direct α-amination. Primary α-amino carbonyls are readily produced under mild conditions, further enabling diverse in situ functionalization reactions—including peptide coupling and Pictet–Spengler cyclization—that capitalize on the presence of the unprotected primary amine.

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Feng, M., Fernandes, A. J., Sirvent, A., Spinozzi, E., Shaaban, S., & Maulide, N. (2023). Free Amino Group Transfer via α-Amination of Native Carbonyls. Angewandte Chemie - International Edition, 62(28). https://doi.org/10.1002/anie.202304990

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