Quantitative Genetic Analysis of Variation in Adult Stature: The Contribution of Path Analysis

Abstract

In textbook discussions of quantitative inheritance, human adult stature is invariably cited as an example of a highly multi-factorial trait, normally distributed in given breeding groups, showing substantial genetic determination, and presenting no evidence of X-linked influence or other major gene effects (see Cavalli-Sforza and Bodmer, 1971). Although continuing research adds more detail to this picture, especially in revealing the contribution of nutrition and other environmental effects, the essential outline remains valid at the present time. In particular, attempts to detect somatic and X-linked major gene influence on adult stature have thus far yielded negative results (Fain, 1978).